感覚・運動神経科学
スタッフ
| 教授 | 山岨 達也 |
|---|---|
| 准教授 | 近藤 健二 |
研究概要
音楽の認知、高度難聴児の人工内耳術後の聴覚･言語･音声の発達、音源定位の知覚、聴覚・平衡覚・嗅覚の障害の機序、治療、再生誘導について研究を行っている。外科学専攻の耳鼻咽喉科学分野と共同研究をしており、障害を持つ患者のデータも得て、動物のみでなく、ヒトでの解析を行うことで、臨床への応用も目指している。
研究項目
１）人工内耳装用者の聴覚認知、音楽聴取、騒音下聴取
２）聴覚障害・平衡覚障害・嗅覚障害の発症機序の解明・治療法の開発
- tansgenic mouse、遺伝子・ｍRNA導入、二光子励起顕微鏡
３）音声言語障害の評価と治療
４）感覚障害のリハビリの開発
- 人工前庭機器、微弱電流刺激、トレーニング機器の開発、AIの応用
mRNA-loaded polyplex nanomicelles（上段) と naked mRNA (下段)の鼻腔内投与
蝸牛全回転におけるコルチ器の透明化・免疫染色による観察
Publication list
- Tuerdi A, et al. S Zone-specific damage of the olfactory epithelium under protein restriction. Sci Rep 2020
- Kakigi A, et al. Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease. Sci Rep 2020
- Kondo K, et al. Age-related olfactory dysfunction: Epidemiology, pathophysiology, and clinical management Front Aging Neurosci 2000
- Urata S, et al. Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning. Elife 2019
- Fujimoto C, et al. Noisy galvanic vestibular stimulation has a greater ameliorating effect on posture in unstable subjects: a feasibility study. Sci Rep. 2019
- Kinoshita M, et al. Alteration of Musashi1 intra-cellular distribution during regeneration following gentamicin-induced hair cell loss in the guinea pig crista ampullaris. Front Cell Neurosci 2019
- Tuerdi A, et al. Dorsal-zone-specific reduction of sensory neuron density in the olfactory epithelium following long-term exercise or caloric restriction. Sci Rep. 2018
- Iwasaki S, et al. Noisy vestibular stimulation increases gait speed in normals and in bilateral vestibulopathy. Brain Stimul. 2018
- Anraku Y, et al. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat Commun. 2017.
- Kamogashira T, et al. Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress. NPJ Aging Mech Dis. 2017.
- Umezawa K, et al. Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics. Nat Chem. 2017
- Fujimoto C, et al. Autophagy is essential for hearing in mice. Cell Death Dis. 2017.
- Matsumoto Y, et al. Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nat Nanotechnol. 2016.
- Kikuta S, et al. Sensory deprivation disrupts homeostatic regeneration of newly generated olfactory sensory neurons after injury in adult mice. J. Neurosci. 2015.
- Baba M, et al. Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles. J Control Release 2015.
- Kikuta S, et al. Odorant response properties of individual neurons in an olfactory glomerular module. Neuron 2013.
- Karino S, et al. Axonal branching patterns as sources of delay in the mammalian auditory brainstem: a re-examination. J Neurosci. 2011.
- Kikuta S, et al. Neurons in the anterior olfactory nucleus pars externa detect right or left localization of odor sources. PNAS 2010.
- Someya S, et al. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. PNAS 2009.
連絡先
tyamasoba-tky@umin.ac.jp