Sensory Moter Neuroscience
Staff
| Prof. | Kenji Kondo |
|---|
Overview
Our research focuses on the function and pathophysiology of the auditory, vestibular, and olfactory organs, which are highly developed sensory systems that allow the body to recognize its internal and external environment, as well as the motor nervous system involved in communication, such as the facial nerve. In collaboration with the Department of Otorhinolaryngology and Head and Neck Surgery in the Division of Surgery, we are conducting analysis using human samples and patient data in addition to analysis of experimental animals, with the aim of applying our research to clinical practice.
Projects
- Hearing, speech, and language development after cochlear implantation in children with congenital deafness
- Research on the development of AI-based infant hearing tests and improvement of cochlear implant treatment outcomes
- Auditory perception and listening in noise for cochlear implant recipients
- Research on sound source localization and the effect of crossed hearing aids in patients with unilateral hearing loss
- Elucidation of pathophysiology and development of treatment and prevention methods using animal models of hearing loss such as senile deafness, acoustic trauma, and Meniere's disease Development of novel treatment methods for equilibrium disorders using vestibular electrical stimulation
- Elucidation of pathophysiology and development of treatment for olfactory disorders using animal models of olfactory mucosa injury
- Analysis of human olfactory mucus and its involvement in olfactory reception
- Development of rehabilitation for sensory disorders, development of training equipment, and biological information monitoring
- Pathophysiology of facial nerve paralysis and development of treatment methods
Anechoic chamber for research on sound localization in patients with unilateral hearing loss and cochlear implant users
An analysis of cochlear sensory epithelium by using tissue clearing
Publication list
- Fujimaki Y, Kondo K, Nishijima H, et al: Granulocyte colony-stimulating factor promotes regeneration of severed facial nerve in rats. Front Neurosci. 2024;18:1442614.
- Kashio A, Yamada C, Yasuhara K, et al: Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse. Hear Res 2023; 428:108678.
- Nishijima H, Zunitch MJ, Yoshida M, et al: Rapid fluorescent vital imaging of olfactory epithelium. iScience 25: 104222, 2022
- Ijichi C, Kondo K, Kobayashi M, et al: Lipocalin 15 in the olfactory mucus is a biomarker for Bowman's gland activity. Sci Rep 12: 9984, 2022
- Koyama H, Kashio A, Fujimoto C, et al: Alteration of Vestibular Function in Pediatric Cochlear Implant Recipients. Front Neurol 12:661302, 2021
- Urata S, Iida T, Yamamoto M, et al: Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning. Elife 8: e40946, 2019
- Kinoshita M, Fujimoto C, Iwasaki S, et al: Alteration of Musashi1 intra-cellular distribution during regeneration following gentamicin-induced hair cell loss in the guinea pig crista ampullaris. Front. Cell. Neurosci 13: 481, 2019
- Iwamura H, Kondo K, Kikuta S, et al: Caloric restriction reduces basal cell proliferation and results in the deterioration of neuroepithelial regeneration following olfactotoxic mucosal damage in mouse olfactory mucosa. Cell Tissue Res 378: 175-193, 2019
- Kamogashira T, Hayashi K, Fujimoto C, et al: Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress. NPJ Aging Mech Dis. 3: 2, 2017
- Fujimoto C, Iwasaki S, Urata S, et al: Autophagy is essential for hearing in mice. Cell Death Dis 8: e2780, 2017
- Fujimoto C, Yamamoto Y, Kamogashira T, et al: Noisy galvanic vestibular stimulation induces a sustained improvement in body balance in elderly adults. Sci Rep 6; 37575, 2016
Contact
kondok-tky@umin.ac.jp