Child Neuropsychiatry
Staff
| Prof. | Shinsuke Koike |
|---|
Overview
The Department of Child Neuropsychiatry primarily conducts research on neurodevelopmental disorders (NDD), such as autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). NDD arises from the differences from typical development in cognition and behaviors, which can sometimes result in difficulties in daily life. To understand NDD, it is essential to understand typical development in the cognition and brain throughout the lifespan. It is also important to examine why people with NDD experience challenges in their daily lives. Society is generally structured around rules and systems that function well for the majority of people. Therefore, when studying NDD, it is important to consider not only biological and psychological aspects but also the social and environmental contexts surrounding each individual.
Projects
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We focus on three topics: child and adolescent psychiatry, neuroimaging, and stigma research. Across all topics, we focus on the changes across the lifespan and investigate not only NDD but also other neuropsychiatric disorders from a broader developmental perspective.
- Clinical Research in Child and Adolescent Psychiatry The Department of Child Psychiatry, The University of Tokyo Hospital, has systematically collected structured clinical records over many years. We also conduct long-term follow-up surveys to understand the psychosocial factors associated with their outcomes and prognosis.
- Brain Development and Aging through the Lifespan, and Neurodevelopmental and Psychiatric Disorders We have conducted multisite brain magnetic resonance image (MRI) studies for not only NDD but also other psychiatric and neurological disorders. Using these large-scale datasets, we perform cross-disorder comparison and apply machine learning classifications. In recent years, we have focused particularly on normative brain development and aging throughout the lifespan. Based on this broader understanding of how the brain changes over time, we examine brain alterations associated with NDD and other psychiatric disorders.
- Stigma Toward People with Neurodevelopmental and Psychiatric Disorders Stigma refers to discrimination, negative attitudes and beliefs, and prejudice and stereotypes toward (or in) individuals who experience mental health problems. Although it may seem evident that stigma exists toward individuals with NDD and psychiatric disorders, this assumption itself may contain implicit biases. We investigate stigma in some longitudinal surveys to examine stigma toward people with mental health problems and related factors. We also explore when and how humans have prejudice and discrimination toward certain groups, along with cognitive development during adolescence.
Publication list
- Tatematsu D, et al. Psychological distress among Japanese high school students during the COVID-19 pandemic: An energy landscape analysis. PLOS Med 2026;23(1):e1004884.
- Koike S, et al. Beyond case-control study in neuroimaging for psychiatric disorders: Harmonizing and utilizing the brain images from multiple sites. Neurosci Biobehav R 2025;171:106063.
- Yamaguchi S, et al. Contact experiences of adolescents and family members are associated with decrease of personal stigma but increase of perceived stigma. J Adolesc 2025;97(6):1569-80.
- Zhu Y, et al. Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk. Mol Psychiatry 2024;29(5):1465-77.
- Shibukawa S, et al. Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia. Transl Psychiatry 2024;14(1):164.
- Shi J and Koike S: Human brain magnetic resonance imaging studies for psychiatric disorders: The current progress and future directions. JMA J 2024;7(2):197-204.
- Cai L, et al. Hippocampal structures among Japanese adolescents before and after the COVID-19 pandemic. JAMA Netw Open 2024;7(2):e2355292.
- Sone M, et al. Structural brain abnormalities in schizophrenia patients with a history and presence of auditory verbal hallucination. Transl Psychiatry 2022;12(1):551.
- Kuroda M, et al. Preliminary efficacy of cognitive-behavioral therapy on emotion regulation in adults with autism spectrum disorder: A pilot randomized waitlist-controlled study. PLoS One 2022;17(11):e0277398.
- Eriguchi Y, et al. A 2-year longitudinal follow-up of quantitative assessment neck tics in Tourette's syndrome. PLoS One 2021;16(12):e0261560.
Contact
c-koike@g.ecc.u-tokyo.ac.jp